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The fonds largely document Dr. Segall's professional activities as a cardiologist. It contains correspondence, notes, experimental notebooks, lecture notes, articles, speeches, patients' records, electrocardiograms, reprints and material pertaining to the Louis Gross Memorial Lectures, 1922-1979. Also included are several electrocardiograph machines, dictation devices, and audio recordings (reel-to-reel tapes, dictation disks, and cassette tapes). In addition, the fonds contain records of Dr. Segall's personal and family correspondence, financial transactions, and various other official and unofficial documents.

The fonds reflects Dr. Ferencz's friendship with the physician Harold N. Segall from the early 1960s until his death in 1990. It contains letters, cards, and postcards Dr. Ferencz received from Dr. Segall, as well as photographs of Dr. Segall and ephemera relating to the Segall-Gross lectures and various celebrations of Dr. Segall's life.