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The fonds consists mainly of a bound notebook that Mussen kept with notes on his experimental investigations. Includes mounted photographs of brain specimens and animal subjects. Fonds also contains loose manuscript notes and two overhead projector transparencies.

The fonds includes American Neurological Association material (1934-1941), army files (1939-1943), correspondence, lecture notes, glass slides, large glass negatives, colour screen filters, and reprints with a card index.

The Penfield fonds consists of over eighty metres of Penfield's personal and professional records dating from his childhood up until his death in 1976, including during his career at the Montreal Neurological Institute. The materials in the fonds include photographs, correspondence, manuscripts and drafts of publications and speeches, research notes, glass slides, bound reports, films, and academic gowns.