The fonds consists of the graduating class photograph, comparative medicine, 1895 and diplomas of H.D. Clark.

Fonds shows Henry Beaumont Small's activities as a medical student through his admission cards for his complete medical formation. It contains 43 admission cards signed by or printed for the teachers, among them William Osler.

Fonds comprises photocopies of three works for the piano, which Blume described as "meine gesammelten Werke" ("my collected works"). Two of these – an arrangement of the "Emperor Waltz", and "Variations on an American Folk-Song" – were written in the Sherbrooke Internment Camp in 1942. The third, "Picture book for Veronika" was written later that year in Toronto.

The Helen Neilson fonds consists of a variety of research notes used as source material for her book on Macdonald College. It includes statistics on students in Household Sciences, as well as names of directors and staff. There are copies of Diaper Dell Doings (1946-1948), Diaper Dell Association pamphlet, which reflects the housing development constructed by McGill University after World War II for the use of student veterans and their families at Macdonald College. Included are also newspaper clippings, notes on teaching and research (1971-1973), and photocopies of sketches of the coat of arms of Macdonald College. There is some correspondence relating to the proposed move to McGill’s downtown campus, the establishment of the provincial CEGEP John Abbott College at Macdonald and the 50th reunion of class 1912 (1917-1952).

Included are Boa's photograph 1906, six certificates, including her Normal School diploma, 1903-1906, and a letter offering her a scholarship in the Faculty of Arts from the University Registrar, 1905.

Student assignment "Engineering Reports 136" completed in 1944.

The fonds contains original and typescript letters, manuscript notes, newspaper clippings, journal extracts, reminiscences and more, assembled by Harvey Cushing chiefly between 1920 and 1924 during the course of his research for the biography of William Osler. For the biography, Cushing collected and retyped over 7500 pieces of Osler's correspondence, among which are some original letters.

The fonds is separated into three series: Manuscripts, Working Notes and Osler's Correspondence. It also contains photographs, annual reports, publications, clippings, one watercolor painting, one postcard. Osler's correspondence is further arranged in three subseries based chronologically.

Selected papers of the Hart Family include a diary kept by Bernard Samuel Judah (an in-law of the Harts) during a voyage to the United States to visit his son Samuel, 1827-1828; a Jewish calendar belonging to Alan Judah Hart with notices of family births and deaths, 1903-1930, and few diary entries, 1917-1919; a few items of correspondence of Alan Hart and his family relating to family history, 1923-1972; some notes on family history, and 25 portraits (photographs, silhouettes) of family members from 1823 to ca 1960.

The fonds documents Swain's career at the Deputy Minister of Indian and Northern Affairs Canada, including his role in the standoff at Oka, Quebec, in 1990. One series also consists of research materials collected during the writing of Swain's 2010 books, Oka: A Political Crisis and its Legacy.