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The fonds illustrates Charles Lewis's work in pharmacy and includes a collection of his father's records, also named Charles Lewis. It contains books, drug formulae books, manuscripts, diplomas, licenses, certificates, patent documents, catalogues, testimonials, notes, correspondence, legal documents, financial documents, business documents, and obituaries.

The greater portion of these records consists of journals, cash books and ledgers recording purchases and sales, 1822-1898. Also included are formula and prescription books, catalogues, price lists, company releases, 1948 and 1952, and a genealogy of the Lyman Family in Canada.