Fonds consists of manuscript essays spanning the years 1847-1903. They comprise his inaugural lecture on pericarditis, reminiscences of early days of the Medical Faculty, several discussions of homoeopathy, and papers on vaccination, the registration of the causes of death and other topics. Eleven volumes of his manuscript lectures "On women's medical problems" are also included.

Fonds shows H.R. Griffith's papers and records pertaining to his introduction of the homeopathic remedy curare into anesthesia. The fonds contains correspondence, case records, and reprints, as well as the minute book of the Montreal Homoeopathic Association, 1863-1968.