Included is the constitution, by-laws, and minute books covering 1922-1940. Approximately one half of this material consists of membership cards recording the name, rank, degrees, and publications of members from 1920 until ca 1970. There are also membership lists for various periods including the founding members and lecture lists, ca 1930s. The secretary's files, covering the period 1963-1969, contain files on dues collected, expenditures, membership (nominations, transfers, correspondence with members), the national convention, and chapter meetings. Financial transactions from 1939 to 1946 are recorded in the treasurer's account book.

The Sir William Osler Collection, distinct from the Bibliotheca, is an extensive archival holding of Osler's correspondence (including eighteen hundred original letters), daybooks, accounts, engagement books, legal documents, book invoices, membership certificates, notebooks, lectures, addresses, newspaper clippings, photographs, books with manuscript additions, and miscellaneous loose items formerly inserted into individual books in his library. The collection also contains various family papers, including correspondence of Lady Grace Revere Osler and Edward Revere Osler.

This archive consists of photocopies of the portion of the ledger of William Lauder, concerning the Arts Building project, 1838-1841. An index to the entire ledger is included.